Acetone sodium bisulfite, also known as sodium bisulfite, adduct of acetone, is a chemical compound used in various industries, including pharmaceuticals, where it serves multiple functions such as antioxidant, preservative, and reducing agent. Here’s how it can be utilized in pharmaceutical applications:


Acetone sodium bisulfite can act as an antioxidant in pharmaceutical formulations to prevent or slow down oxidation reactions that may lead to the degradation of active pharmaceutical ingredients (APIs) or other components in the formulation. By scavenging free radicals and reactive oxygen species, acetone sodium bisulfite helps maintain the stability and efficacy of pharmaceutical products, particularly those susceptible to oxidative degradation.


Acetone sodium bisulfite can function as a preservative in pharmaceutical formulations to inhibit the growth of microorganisms such as bacteria and fungi. By releasing bisulfite ions (SO3^-) in solution, acetone sodium bisulfite creates an acidic environment that is inhospitable to many microbial species, thereby extending the shelf life and maintaining the sterility of pharmaceutical preparations, such as injectable solutions and ophthalmic products.

Reducing Agent

Acetone sodium bisulfite serves as a reducing agent in pharmaceutical formulations, where it facilitates chemical reactions involving the reduction of functional groups or the regeneration of active species. For example, it can be used to reduce aldehydes or ketones to their corresponding alcohols, or to regenerate antioxidant compounds that may have undergone oxidation during storage or processing.


In addition to its antioxidant properties, acetone sodium bisulfite can act as a stabilizer in pharmaceutical formulations by preventing or minimizing the degradation of sensitive compounds in the presence of oxygen, light, or heat. It helps maintain the chemical integrity and potency of pharmaceutical products throughout their shelf life.

pH Modifier

Acetone sodium bisulfite can be used as a pH modifier in pharmaceutical formulations to adjust the acidity or alkalinity of the solution to a desired level. By buffering the pH of the formulation, acetone sodium bisulfite helps optimize the stability and solubility of the active ingredients and enhances the overall compatibility with physiological conditions.